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Article

Activating Gs a mutation rarely occurs in musculoskeletal tumors other than fibrous dysplasia.

Anticancer research - 1 Jan 2000

Gu Wenguang, Ogose Akira, Matsuba Atsushi, Kawashima Hiroyuki, Hotta Tetsuo, Kudo Naoko, Hoshino Makiko, Kondo Naoki, Mera Hisashi, Endo Naoto

Abstract excerpt

BACKGROUND: Activating Gs a mutations have been identified in most instances of fibrous dysplasia (FD). This mutation leads to consistently elevated intracellular cyclic adenosine monophosphate (cAMP) levels, with various biological consequences. The development of secondary sarcoma in FD is a rare but well-established phenomenon. This finding raised the possibility that a common gene mutation exists in these...

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PMID: 16619580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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