Article
Quantitative analysis of activating alpha subunit of the G protein (Gsα) mutation by pyrosequencing in fibrous dysplasia and other bone lesions.
The Journal of molecular diagnostics : JMD - 1 Mar 2011
Liang Qi, Wei Minqi, Hodge LeAnn, Fanburg-Smith Julie C, Nelson Ann, Miettinen Markku, Foss Robert D, Wang Guanghua
Abstract excerpt
Benign fibro-osseous lesions (BFOLs) frequently display overlapping histological features. The differentiation of fibrous dysplasia (FD) from other BFOLs can be difficult, even for experienced orthopedic pathologists. Accurately distinguishing FD from other BFOLs may have significant clinical and treatment implications. A somatic mutation in gene GNAS encoding the α subunit of the G protein (Gsα) involving the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.