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Article

Analysing the effect of candidate genes on complex traits: an application in multiple sclerosis.

Immunogenetics - 1 Jun 2006

Hooper-van Veen Tineke, Berkhof Johannes, Polman Chris H, Uitdehaag Bernard M J

Abstract excerpt

The conventional approach of candidate gene studies in complex diseases is to look at the effect of one gene at a time. However, as the outcome of chronic diseases is influenced by a large number of alleles, simultaneous analysis is needed. We demonstrate the application of multivariate regression and cluster analysis to a multiple sclerosis (MS) dataset with genotypes for 489 patients at 11 candidate genes...

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PMID: 16612628
DOI: 10.1007/s00251-006-0116-3

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