Article
Membership in genetic groups predicts Alzheimer disease.
Rejuvenation research - 1 Jan 2006
Corder Elizabeth H, Huang Rong, Cathcart Heather M, Lanham Irene S, Parker Ginny R, Cheng Danny, Smith Suzanne, Poduslo Shirley E
Abstract excerpt
The multiple polymorphisms contributing to Alzheimer disease (AD) have been difficult to identify. Three essentially sufficient risk sets were found using a fuzzy latent classification statistical model; that is, grade-of-membership analysis, and genotypes for APOE, APOCI, LDLr, cystatin C, and cathepsin D (180 cases, 120 controls). These were: (a) CST3:GA and CTSD:CT; (b) APOE44 and LDLr8:GG and LDLr13:TT; and...
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