Article
The genotypic inhibitory quotient and the (cumulative) number of mutations predict the response to lopinavir therapy.
AIDS (London, England) - 24 Apr 2006
Hoefnagel Jolanda G M, van der Lee Manon J, Koopmans Peter P, Schuurman Rob, Jurriaans Suzanne, van Sighem Ard I, Gras Luuk, de Wolf Frank, Galama Jochem M D, Burger David M
Abstract excerpt
For 95 protease inhibitor-experienced HIV-1-infected patients, the genotypic inhibitory quotient (GIQ; trough level/number of mutations) was calculated for lopinavir. Three different sets of mutations showed equal predictive value. However, the use of cumulative numbers of mutations for calculation of the GIQ showed significantly better association with the virological response. Furthermore, the predictive value...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.