Article
Distinction between hereditary and sporadic breast cancer on the basis of clinicopathological data.
Journal of clinical pathology - 1 Jun 2006
van der Groep P, Bouter A, van der Zanden R, Siccama I, Menko F H, Gille J J P, van Kalken C, van der Wall E, Verheijen R H M, van Diest P J
Abstract excerpt
BACKGROUND: About 5% of all breast cancer cases are attributable to germline mutations in BRCA1 or BRCA2 genes. BRCA mutations in suspected carriers, however, may be missed, which hampers genetic counselling. MATERIALS AND METHODS: Different clinicopathological features were compared between 22 breast cancers from carriers of proved BRCA1 mutations and 604 cancers from sporadic controls. In addition, 5...
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