Article
Proteomic analysis of anaplastic lymphoma cell lines: identification of potential tumour markers.
Proteomics - 1 May 2006
Cussac Daniel, Pichereaux Carole, Colomba Audrey, Capilla Florence, Pont Frédéric, Gaits-Iacovoni Frédérique, Lamant Laurence, Espinos Estelle, Burlet-Schiltz Odile, Monsarrat Bernard, Delsol Georges, Payrastre Bernard
Abstract excerpt
Anaplastic large-cell lymphomas (ALCL) are high grade lymphomas of T or null phenotype often associated with the t(2;5) translocation leading to the expression of a chimeric protein consisting of the N-terminal portion of nucleophosmin (NPM) and the intracellular domain of the anaplastic lymphoma kinase (ALK). Although ALCL are recognized as distinct clinical, biological and cytogenetic entities, heterogeneities...
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