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Article

Integrating basal and reserve salivary function defines clinically anchored functional phenotypes and contextualises salivary end points in Sjögren's disease.

RMD open - 8 Jul 2026

Cheng Chiao-Feng, Lan Ting-Yuan, Kao Jui-Hung, Chen Tseng-Cheng, Hsieh Min-Shu, Lin Yu-Heng, Huang Yi-Min, Chen Yi-Chieh, Cheng Mei-Fang, Chu Hsiao-Sang, Lu Cheng-Hsun, Shen Chieh-Yu, Li Ko-Jen, Hsieh Song-Chou

Abstract excerpt

BACKGROUND: Salivary gland dysfunction in Sjögren's disease (SjD) is clinically heterogeneous. Unstimulated whole salivary flow (UWSF) reflects basal secretion, while stimulated tests such as the Saxon test assess secretory reserve. Whether integrating these complementary domains defines clinically meaningful glandular functional states remains unclear. METHODS: We conducted a retrospective cohort study of 193...

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Phenotype
Saliva
Salivary Glands
Sjogren's Syndrome

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PMID: 42419786
DOI: 10.1136/rmdopen-2026-006843
PMCID: PMC13347809

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