Article
Domain specificity of factor VIII inhibitors during immune tolerance induction in patients with haemophilia A.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 Nov 2010
van Helden P M W, Kaijen P H P, Mauser-Bunschoten E P, Fischer K, van den Berg H M, Voorberg J
Abstract excerpt
UNLABELLED: INTRODUCTION: Frequent administration of high dosages factor VIII (FVIII), so-called immune tolerance induction (ITI), provides an efficient strategy to eradicate inhibitory antibodies in patients with haemophilia A. At present, our knowledge on the characteristics of inhibitory antibodies in patients undergoing ITI is limited. AIM: In this study we characterized the domain specificity of FVIII...
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