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Spontaneous disappearance of high titre factor VIII inhibitor 15 years after unsuccessful ITI.

Hamostaseologie - 1 May 2009

Thom K, Male Christoph, Falger J, Pabinger I

Abstract excerpt

The most serious complication of haemophilia A is development of a high-titre factor VIII (FVIII) inhibitor which renders the patient unresponsive to FVIII replacement. Bleeding complications can only be controlled using FVIII-inhibitor bypassing agents but their effect is less certain. The ultimate goal is to eliminate the inhibitor by immune tolerance induction therapy (ITI) using daily high doses of FVIII. The...

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PMID: 19404512

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