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Article

Regulation of CYP1A1 gene expression by the antioxidant tert-butylhydroquinone.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2006

Schreiber Thomas D, Köhle Christoph, Buckler Felicitas, Schmohl Stefan, Braeuning Albert, Schmiechen Alexander, Schwarz Michael, Münzel Peter A

Abstract excerpt

CYP1A1, a major phase I enzyme, plays an important role in the metabolism of polycyclic aromatic hydrocarbons and in the chemical activation of xenobiotics to carcinogenic derivatives. The phenolic antioxidant tert-butylhydroquinone (tBHQ), often used as a food preservative, is generally considered to act only as a mono-functional inducer of phase II enzymes, thereby exerting chemo-protection. However, we...

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PMID: 16581943
DOI: 10.1124/dmd.106.009662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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