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Article

Functional phenotyping of human plasma using a 361-fluorogenic substrate biosensing microarray.

Biotechnology and bioengineering - 20 Aug 2006

Gosalia Dhaval N, Denney William S, Salisbury Cleo M, Ellman Jonathan A, Diamond Scott L

Abstract excerpt

A microarray presenting glycerol nanodroplets of fluorogenic peptide substrates was used as a biosensor for the detection of multiple enzyme activities within human plasma. Using 10 different plasma proteases (kallikrein, factor XIIa, factor XIa, factor IXa, factor VIIa, factor Xa, thrombin, activated protein C, uPA and plasmin) and a 361-compound fluorogenic substrate library (Ac-Ala-P3-P2-Arg-coumarin for P =...

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Identifiers

PMID: 16575920
DOI: 10.1002/bit.20927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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