Comparative expression profiling in primary and immortalized endothelial cells: changes in gene expression in response to hydroxy methylglutaryl-coenzyme A reductase inhibition

Abstract excerpt

Immortalized cell lines offer significant logistical advantages over primary cells when used for in-vitro studies. Immortalized cells may, however, exhibit important differences relative to their primary cell counterparts. In this study, microarrays were used to make a genome-wide comparison between primary human umbilical vein endothelial cells (HUVECs) and EA.hy926, an immortalized HUVEC cell line, in their...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Lipoproteins and Cardiovascular Health
• Share to Nuclear Receptors and Signaling
• Share to Protease and Inhibitor Mechanisms