Article
Chromosome 9 deletions are more frequent than FGFR3 mutations in flat urothelial hyperplasias of the bladder.
International journal of cancer - 1 Sept 2006
van Oers Johanna M M, Adam Christoph, Denzinger Stefan, Stoehr Robert, Bertz Simone, Zaak Dirk, Stief Christian, Hofstaedter Ferdinand, Zwarthoff Ellen C, van der Kwast Theodorus H, Knuechel Ruth, Hartmann Arndt
Abstract excerpt
Flat urothelial hyperplasias (FUHs) in patients with papillary bladder tumours frequently show deletions of chromosome 9, suggesting that FUH could be the first neoplastic step in the development of papillary bladder cancer. FGFR3 mutations are frequent in non-invasive papillary tumours with low risk of progression. Our aim was to investigate the frequency of FGFR3 mutations and deletions of chromosomes 9p/q and...
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