Single-nucleotide polymorphisms of VEGF gene are associated with risk of congenital valvuloseptal heart defects.

doi:10.1016/j.ahj.2005.10.012

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Article

Single-nucleotide polymorphisms of VEGF gene are associated with risk of congenital valvuloseptal heart defects.

American heart journal - 1 Apr 2006

Vannay Adám, Vásárhelyi Barna, Környei Mária, Treszl András, Kozma Gergely, Györffy Balázs, Tulassay Tivadar, Sulyok Endre

Abstract excerpt

BACKGROUND: Disturbed vascular endothelial growth factor (VEGF) production during early heart morphogenesis causes endocardial cushion malformation, which results in congenital heart disease (CHD). We tested whether functional VEGF -460T/C and +405G/C polymorphisms that have an impact on VEGF levels were associated with CHD. METHODS: Dried blood samples were collected from 102 CHD children and 112 healthy control...

Topics

Carrier State
Child
Child, Preschool
Endocardial Cushion Defects
Female
Genotype
Heart Septal Defects
Heart Valve Diseases
Humans
Linkage Disequilibrium
Male
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Vascular Endothelial Growth Factor A

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Open in PubMed

Identifiers

PMID: 16569553
DOI: 10.1016/j.ahj.2005.10.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.