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Article

VEGF polymorphisms are associated with endocardial cushion defects: a family-based case-control study.

Pediatric research - 1 Jan 2010

Smedts Huberdina P M, Isaacs Aaron, de Costa Dominique, Uitterlinden André G, van Duijn Cornelia M, Gittenberger-de Groot Adriana C, Helbing Willem A, Steegers Eric A P, Steegers-Theunissen Régine P M

Abstract excerpt

UNLABELLED: Endocardial cushion defects (ECDs) of the cardiac outflow tract are among the most common congenital heart disease phenotypes. VEGF is essential for endocardial cushion formation and derangements in VEGF synthesis lead to ECD. Three functional single nucleotide polymorphisms (SNPs) in the VEGF gene -2578 C>A, -1154 G>A, and -634 G>C play a role in cardiogenesis. In a Dutch case-control family study of...

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Identifiers

PMID: 19816237
DOI: 10.1203/PDR.0b013e3181c1b144

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ECD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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