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Article

Protein assembly and DNA looping by the FokI restriction endonuclease.

Nucleic acids research - 1 Jan 2006

Catto Lucy E, Ganguly Sumita, Milsom Susan E, Welsh Abigail J, Halford Stephen E

Abstract excerpt

The FokI restriction endonuclease recognizes an asymmetric DNA sequence and cuts both strands at fixed positions upstream of the site. The sequence is contacted by a single monomer of the protein, but the monomer has only one catalytic centre and forms a dimer to cut both strands. FokI is also known to cleave DNA with two copies of its site more rapidly than DNA with one copy. To discover how FokI acts at a...

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PMID: 16556912
DOI: 10.1093/nar/gkl076
PMCID: PMC1410913

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