Article
Cytomegalovirus interleukin-10 expression in infected cells does not impair MHC class I restricted peptide presentation on bystanding antigen-presenting cells.
Viral immunology - 1 Jan 2006
Pepperl-Klindworth Sandra, Besold Katrin, Frankenberg Nadine, Farkas Mildred, Kuball Jürgen, Theobald Matthias, Plachter Bodo
Abstract excerpt
Human cytomegalovirus (HCMV) has evolved strategies to counteract its surveillance by the immune system. Mitigation of antiviral immune responses is considered critical for establishment of viral latency and for spread. Recently, a gene encoding an interleukin-10 homologue (cmvIL-10) has been discovered in the HCMV genome. Using recombinant cmvIL-10, several mostly immunosuppressive functions of the molecule have...
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