Article
Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan.
Cancer research - 15 Oct 1991
Elmore L W, Sirica A E
Abstract excerpt
In order to investigate the early cellular changes in liver associated with furan cholangiocarcinogenesis, young adult male Fischer 344 rats were administered furan by gavage once a day, 5 days a wk for 2 to 3 wk at doses ranging from 15 to 60 mg/kg of body weight per day. The most conspicuous fe...
Topics
- Adenoma, Bile Duct
- Animals
- Bile Duct Neoplasms
- Bile Ducts, Intrahepatic
- Dose-Response Relationship, Drug
- Female
- Furans
- Intestines
- Liver
- Liver Neoplasms
- Male
- Metaplasia
- Microscopy, Electron
- Phenotype
- Rats
- Rats, Inbred F344