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β-Lactam Antibiotics Induce the SOS Response and Horizontal Transfer of Virulence Factors in<i>Staphylococcus aureus</i>

17 Mar 2006

Abstract excerpt

Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that beta-lactams induce a bona fide SOS response in S. aureus, characterized by the activation of the RecA and LexA proteins, the two...

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PMID: 16547063
DOI: 10.1128/jb.188.7.2726-2729.2006

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