Article
Mechanism of a genetic glissando: structural biology of indel mutations.
Trends in biochemical sciences - 1 Apr 2006
Garcia-Diaz Miguel, Kunkel Thomas A
Abstract excerpt
Insertions and deletions of bases in DNA (collectively termed "indels") are both common and biologically relevant, being associated with different human pathologies including cancer and diseases associated with expansions of repeats. Four decades of research have resulted in several hypotheses regarding how indels are generated during DNA synthesis and how they subsequently undergo or escape correction. Recent...
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