Alymphoplasia mice are resistant to prion infection via oral route.

Abstract excerpt

The major cause of infection in animal prion diseases is thought to be consumption of prion-contaminated stuff. There is evidence that the enteric nerve system (ENS) and gut-associated lymphoid tissues (GATL) are involved in the establishment of prion infection through alimentary tract. To elucidate the initial entry port for prion, we inoculated prion to alymphoplasia (aly) mice showing a deficiency in systemic...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Administration, Oral
• Share to Gastrointestinal Tract
• Share to Mice, Inbred C57BL