Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses.

The Journal of clinical investigation - 1 Apr 2006

Amedei Amedeo, Cappon Andrea, Codolo Gaia, Cabrelle Anna, Polenghi Alessandra, Benagiano Marisa, Tasca Elisabetta, Azzurri Annalisa, D'Elios Mario Milco, Del Prete Gianfranco, de Bernard Marina

Abstract excerpt

The Helicobacter pylori neutrophil-activating protein (HP-NAP) is a virulence factor of H. pylori that stimulates in neutrophils high production of oxygen radicals and adhesion to endothelial cells. We report here that HP-NAP is a TLR2 agonist able to induce the expression of IL-12 and IL-23 by neutrophils and monocytes. Addition in culture of HP-NAP, as an immune modulator, to antigen-induced T cell lines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Th1 Cells
Share to Allergens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD4 Antigens

Share to Genes, MHC Class II

Share to Granulocytes

Share to Interleukin-12

Share to Interleukin-23

Share to Toll-Like Receptor 2

Source

Open in PubMed Open full text

Identifiers

PMID: 16543949
DOI: 10.1172/JCI27177
PMCID: PMC1401483

Genes

TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses.PMID 16543949Read ↗

<i>Helicobacter pylori</i>neutrophil-activating protein: From molecular pathogenesis to clinical applicationsSemantic proximity Read ↗

Impact of cagPAI and T4SS on the inflammatory response of human neutrophils to Helicobacter pylori infection.Semantic proximity Read ↗

Activation of NLRP3 inflammasome in human neutrophils by Helicobacter pylori infectionSemantic proximity Read ↗

Innate immune activation and modulatory factors of Helicobacter pylori towards phagocytic and nonphagocytic cellsSemantic proximity Read ↗

Helicobacter pylori neutrophil-activating protein stimulates tissue factor and plasminogen activator inhibitor-2 production by human blood mononuclear cells.Semantic proximity Read ↗

Helicobacter pylori antigens as potential modulators of lymphocytes' cytotoxic activity.Semantic proximity Read ↗

Unveiling the crucial role of type IV secretion system and motility of <i>Helicobacter pylori</i> in IL-1β production via NLRP3 inflammasome activation in neutrophilsSemantic proximity Read ↗

Serum Antibodies against Helicobacter pylori Neutrophil Activating Protein in Carriers of IL-4 C-590T Genetic Polymorphism Amplify the Risk of Gastritis and Gastric Cancer.Semantic proximity Read ↗

Cutting Edge: Helicobacter pylori Induces Nuclear Hypersegmentation and Subtype Differentiation of Human Neutrophils In Vitro.Semantic proximity Read ↗

The innate immune molecule, NOD1, regulates direct killing of<i>Helicobacter pylori</i>by antimicrobial peptidesSemantic proximity Read ↗

An Attempt to Polarize Human Neutrophils Toward N1 and N2 Phenotypes in vitro.Semantic proximity Read ↗

Pathogenic implications of interleukin-8 activity and bacterial phenotype in antral gastritis associated with Helicobacter pylori.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.