Article
Serum Antibodies against Helicobacter pylori Neutrophil Activating Protein in Carriers of IL-4 C-590T Genetic Polymorphism Amplify the Risk of Gastritis and Gastric Cancer.
Iranian biomedical journal - 1 Sept 2017
Talebkhan Yeganeh, Doozbakhshan Mohsen, Saberi Samaneh, Esmaeili Maryam, Karami Najmeh, Mohajerani Nazanin, Abdirad Afshin, Eshagh Hosseini Mahmoud, Nahvijou Azin, Mohagheghi Mohammad Ali, Mohammadi Marjan
Abstract excerpt
BACKGROUND: Gastric cancer arises, mainly, on an inflammatory background. Helicobacter pylori neutrophil activating (HP-NAP) protein functions as a potent pro-inflammatory mediator. Similarly, IL-4 plays a critical role in the inflammation pathway, the levels of which are altered by C to T transition at position -590 in its promoter region. Here, we have aimed to assess the risk of gastritis and gastric cancer in...
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