Article
[Leptin level and the PPARgamma2 Pro12Ala and Pro115Gln polymorphisms in women with functional hyperandrogenism. Preliminary report].
Przeglad lekarski - 1 Jan 2005
Bidzińska-Speichert Bozena, Demissie Marek, Tworowska Urszula, Slezak Ryszard, Dobosz Tadeusz, Bednarek-Tupikowska Grazyna, Milewicz Andrzej
Abstract excerpt
UNLABELLED: Hyperandrogenism is a multifactoral chronic disease, characterised by an androgen excess, often connected with obesity, hirsutism, polycystic ovaries, hyperinsulinemia, insulin resistance and hyperleptynemia. Peroxisome proliferator activated receptors (PPARgamma) are one of the factors influencing insulin sensitivity. As a transcriptional factor it plays a crucial role in the regulation of genes...
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