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Article

Lack of a 5' non-coding region in Tn1721 encoded tetR mRNA is associated with a low efficiency of translation and a short half-life in Escherichia coli.

Nucleic acids research - 11 Sept 1991

Baumeister R, Flache P, Melefors O, von Gabain A, Hillen W

Abstract excerpt

The repressor-encoding tetR gene from Tn1721 is expressed with a very low efficiency. Its mRNA lacks an untranslated leader sequence. We have constructed protein fusions with the lacZ gene which contain between 14 and 157 5' nucleotides from the tetR gene. Since they are all expressed with similar efficiencies we conclude that the sequence information for initiation of translation is contained within the first 14...

Topics

Base Sequence
DNA Transposable Elements
Escherichia coli
Gene Expression Regulation, Bacterial
Kinetics
Molecular Sequence Data
Mutation
Protein Sorting Signals
RNA, Messenger
Recombinant Fusion Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Repressor Proteins

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Identifiers

PMID: 1653948
DOI: 10.1093/nar/19.17.4595
PMCID: PMC328697

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1653948-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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