Article
Common mutations in BRCA1 and BRCA2 do not contribute to early prostate cancer in Jewish men.
The Prostate - 1 Aug 1999
Nastiuk K L, Mansukhani M, Terry M B, Kularatne P, Rubin M A, Melamed J, Gammon M D, Ittmann M, Krolewski J J
Abstract excerpt
BACKGROUND: Families with a high incidence of hereditary breast cancer, and subsequently shown to have terminating mutations in BRCA1 or BRCA2, appear to have a higher incidence of prostate cancer among male relatives. We aimed to determine whether the common germline mutations of BRCA1 or BRCA2 in Ashkenazi Jewish men predisposed them to prostate cancer. METHODS: We examined genomic DNA from 83 (for BRCA1...
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