Article
The role of endogenous growth hormone-releasing hormone in acromegaly.
The Journal of clinical endocrinology and metabolism - 1 Jun 2006
Dimaraki Eleni V, Chandler William F, Brown Morton B, Jaffe Craig A, Kim Soo Y, Taussig Ronald, Padmanabhan Vasantha, Barkan Ariel L
Abstract excerpt
CONTEXT: Some indirect evidence suggests hypothalamic control of GH secretion in acromegaly. OBJECTIVE: The objective of the study is to examine whether GH secretion in acromegaly is dependent on endogenous GHRH. PATIENTS AND STUDY DESIGN: We studied eight patients with untreated acromegaly due to a GH-producing pituitary tumor. All patients received an iv infusion of normal saline for 24 h and GHRH-antagonist...
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