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Article

A polymorphism in the growth hormone-releasing hormone receptor gene: clinical significance?

Regulatory peptides - 15 Oct 2002

Adams Eric F, Oikonomou Eftychia, Bhamrah Mandeep, Buchfelder Michael, Mitchell Rosalind, Poyner David R

Abstract excerpt

Two forms of the growth hormone-releasing hormone (GHRH) receptor (GHRH-R) exist in terms of a polymorphism at codon 57. The most common allele possesses GCG, coding for Ala. This codon can also be ACG, replacing the Ala with Thr. The present study demonstrates that the latter occurs in about 20% of pituitary somatotrophinomas, removed from patients with acromegaly. Somatotrophinomas possessing the alternative...

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Source

Identifiers

PMID: 12220735
DOI: 10.1016/s0167-0115(02)00101-5

Genes

GHRH
GCG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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