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Article

Recovery of a Neurovirulent Human Coronavirus OC43 from an Infectious cDNA Clone

14 Mar 2006

Abstract excerpt

This study describes the assembly of a full-length cDNA clone of human coronavirus (HCoV)-OC43 in a bacterial artificial chromosome (BAC). The BAC containing the full-length infectious cDNA (pBAC-OC43(FL)) was assembled using a two-part strategy. The first step consisted in the introduction of each end of the viral genome into the BAC with accessory sequences allowing proper transcription. The second step...

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PMID: 16537637
DOI: 10.1128/jvi.80.7.3670-3674.2006

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