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Article

Functional analysis of Ca3.2 T-type calcium channel mutations linked to childhood absence epilepsy.

Epilepsia - 1 Mar 2006

Peloquin Jean B, Khosravani Houman, Barr Wendy, Bladen Chris, Evans Rhian, Mezeyova Janette, Parker David, Snutch Terrance P, McRory John E, Zamponi Gerald W

Abstract excerpt

PURPOSE: Childhood absence epilepsy (CAE) is an idiopathic form of seizure disorder that is believed to have a genetic basis. METHODS: We examined the biophysical consequences of seven mutations in the Ca(v)3.2 T-type calcium channel gene linked to CAE. RESULTS: Of the channel variants examined, one of the mutants, a replacement of glycine 848 in the domain II-S2 region with serine, resulted in significant...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16529636
DOI: 10.1111/j.1528-1167.2006.00482.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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