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Article

Gating effects of a Cav2.3 calcium channel variant linked to developmental and epileptic encephalopathy.

Neuroscience - 11 Sept 2026

Khousakoun Devon, Souza Ivana A, Ferron Laurent, Gandini Maria A, Zamponi Gerald W

Abstract excerpt

Developmental and epileptic encephalopathies (DEEs) are a group of neurological disorders that primarily affect young children and are characterized by severe seizures. DEEs are challenging to manage, with some patients experiencing severe side effects or not responding to frontline therapies. The CACNA1E gene, which encodes the voltage-gated calcium channel Cav2.3 (R-type), has recently been associated with...

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Identifiers

PMID: 42392563
DOI: 10.1016/j.neuroscience.2026.07.001

Genes

CACNA1E

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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