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Article

Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5.

PloS one - 1 Jan 2015

Kinnunen Sini, Välimäki Mika, Tölli Marja, Wohlfahrt Gerd, Darwich Rami, Komati Hiba, Nemer Mona, Ruskoaho Heikki

Abstract excerpt

AIMS: Transcription factor GATA4 is a dosage sensitive regulator of heart development and alterations in its level or activity lead to congenital heart disease (CHD). GATA4 has also been implicated in cardiac regeneration and repair. GATA4 action involves combinatorial interaction with other cofactors such as NKX2-5, another critical cardiac regulator whose mutations also cause CHD. Despite its critical...

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Identifiers

PMID: 26642209
DOI: 10.1371/journal.pone.0144145
PMCID: PMC4671672

Genes

GATA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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