Increased monocyte oxidase activity in cystic fibrosis heterozygotes and homozygotes.

doi:10.1165/ajrcmb/5.1.27

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Article

Increased monocyte oxidase activity in cystic fibrosis heterozygotes and homozygotes.

American journal of respiratory cell and molecular biology - 1 Jul 1991

Regelmann W E, Skubitz K M, Herron J M

Abstract excerpt

Freshly isolated monocytes from cystic fibrosis (CF) heterozygotes and homozygotes had significantly increased oxygen uptake and superoxide formation after surface glycoprotein stimulation than did monocytes from age- and sex-matched controls. Lack of differences among the genotypes in inhibition by simple sugars of the concanavalin A-stimulated superoxide production and lack of differences in concanavalin...

Topics

Adolescent
Adult
Child
Concanavalin A
Cystic Fibrosis
Electron Transport Complex IV
Female
Genetic Carrier Screening
Genotype
Homozygote
Humans
Luminescent Measurements

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Membrane Proteins

Monocytes

Oxidoreductases

Oxygen Consumption

Peroxidases

Source

Open in PubMed

Identifiers

PMID: 1652266
DOI: 10.1165/ajrcmb/5.1.27

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1652266-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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