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Article

Gene profiling of polycystic kidneys.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Jul 2006

Schieren Gisela, Rumberger Brigitta, Klein Marinella, Kreutz Clemens, Wilpert Jochen, Geyer Marcel, Faller Daniel, Timmer Jens, Quack Ivo, Rump Lars Christian, Walz Gerd, Donauer Johannes

Abstract excerpt

BACKGROUND: While the genetic basis of autosomal dominant polycystic kidney disease (ADPKD) has been clearly established, the pathogenesis of renal failure in ADPKD remains elusive. Cyst formation originates from proliferating renal tubular epithelial cells that de-differentiate. Fluid secretion with cyst expansion and reactive changes in the extracellular matrix composition combined with increased apoptosis and...

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PMID: 16520345
DOI: 10.1093/ndt/gfl071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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