Article
Critical roles of Leu99 and Leu115 at the heme distal side in auto-oxidation and the redox potential of a heme-regulated phosphodiesterase from Escherichia coli.
The FEBS journal - 1 Mar 2006
Yokota Nao, Araki Yasuyuki, Kurokawa Hirofumi, Ito Osamu, Igarashi Jotaro, Shimizu Toru
Abstract excerpt
The heme-regulated phosphodiesterase from Escherichia coli (Ec DOS), which is a heme redox-dependent enzyme, is active with a ferrous heme but inactive with a ferric heme. Global structural changes including axial ligand switching and a change in the rigidity of the FG loop accompanying the heme redox change may be related to the dependence of Ec DOS activity on the redox state. Axial ligands such as CO, NO, and...
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