Article
Conversion of a heme-based oxygen sensor to a heme oxygenase by hydrogen sulfide: effects of mutations in the heme distal side of a heme-based oxygen sensor phosphodiesterase (Ec DOS).
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine - 1 Oct 2013
Du Yongming, Liu Gefei, Yan Yinxia, Huang Dongyang, Luo Wenhong, Martinkova Marketa, Man Petr, Shimizu Toru
Abstract excerpt
The heme-based oxygen-sensor phosphodiesterase from Escherichia coli (Ec DOS), is composed of an N-terminal heme-bound oxygen sensing domain and a C-terminal catalytic domain. Oxygen (O2) binding to the heme Fe(II) complex in Ec DOS substantially enhances catalysis. Addition of hydrogen sulfide (H2S) to the heme Fe(III) complex in Ec DOS also remarkably stimulates catalysis in part due to the heme Fe(III)-SH and...
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