Loss of constitutive activity of the growth hormone secretagogue receptor in familial short stature

Abstract excerpt

The growth hormone (GH) secretagogue receptor (GHSR) was cloned as the target of a family of synthetic molecules endowed with GH release properties. As shown recently through in vitro means, this receptor displays a constitutive activity whose clinical relevance is unknown. Although pharmacological studies have demonstrated that its endogenous ligand--ghrelin--stimulates, through the GHSR, GH secretion and...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Growth Hormone and Insulin-like Growth Factors
• Share to Lipid metabolism and disorders
• Share to Regulation of Appetite and Obesity