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Article

Abnormal costimulatory phenotype and function of dendritic cells before and after the onset of severe murine lupus.

Arthritis research & therapy - 1 Jan 2006

Colonna Lucrezia, Dinnall Joudy-Ann, Shivers Debra K, Frisoni Lorenza, Caricchio Roberto, Gallucci Stefania

Abstract excerpt

We analyzed the activation and function of dendritic cells (DCs) in the spleens of diseased, lupus-prone NZM2410 and NZB-W/F1 mice and age-matched BALB/c and C57BL/6 control mice. Lupus DCs showed an altered ex vivo costimulatory profile, with a significant increase in the expression of CD40, decreased expression of CD80 and CD54, and normal expression of CD86. DCs from young lupus-prone NZM2410 mice, before the...

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Identifiers

PMID: 16507174
DOI: 10.1186/ar1911
PMCID: PMC1526610

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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