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Genetic variation reveals the enhanced microbial hyaluronan biosynthesis via atmospheric and room temperature plasma.

Carbohydrate polymers - 15 Jul 2023

Yao Zhi-Yuan, Gong Jin-Song, Liu Yu-Ru, Jiang Jia-Yu, Zhang Yue-Sheng, Su Chang, Li Heng, Kang Chuan-Li, Liu Lei, Xu Zheng-Hong, Shi Jin-Song

Abstract excerpt

This study reveals the genetic and biochemical changes underlying the enhanced hyaluronan (HA) biosynthesis in Streptococcus zooepidemicus. After multiple rounds of atmospheric and room temperature plasma (ARTP) mutagenesis combined with novel bovine serum albumin/cetyltrimethylammonium bromide coupled high-throughput screening assay, the HA yield of the mutant was increased by 42.9% and reached 0.813 g L-1 with...

Topics

Hyaluronic Acid
Temperature
Streptococcus equi
Uridine Diphosphate
Genetic Variation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37059520
DOI: 10.1016/j.carbpol.2023.120809

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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