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Article

Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS).

American heart journal - 1 Mar 2006

Burdon Kathryn P, Langefeld Carl D, Beck Stephanie R, Wagenknecht Lynne E, Carr J Jeffrey, Rich Stephen S, Freedman Barry I, Herrington David, Bowden Donald W

Abstract excerpt

BACKGROUND: CD40/CD40L signaling is known to play an important role in immune response. The proteins are expressed in a variety of cell types and ligation causes cells to produce inflammatory cytokines and cellular adhesion molecules. These processes are implicated in the development and progression of atherosclerosis. Animal models demonstrate that interruption of CD40/CD40L signaling produces a more fibrous and...

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Identifiers

PMID: 16504636
DOI: 10.1016/j.ahj.2005.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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