Article
CD40 Gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population.
TheScientificWorldJournal - 1 Jan 2012
Kuo Ho-Chang, Chao Mei-Chyn, Hsu Yu-Wen, Lin Ying-Chi, Huang Ying-Hsien, Yu Hong-Ren, Hou Ming-Feng, Liang Chi-Di, Yang Kuender D, Chang Wei-Chiao, Wang Chih-Lu
Abstract excerpt
BACKGROUND: Kawasaki disease (KD) is characterized by systemic vasculitis of unknown etiology. Our previous studies showed expression of CD40 ligand on CD4+ T cells correlated to the coronary artery lesion (CAL) and disease progress in KD. Other studies from Japan suggested the role of CD40L in the pathogenesis of CAL, and this might help explain the excessive number of males affected with KD but cannot be...
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