Article

Systematic analysis and prediction of genes associated with disorders on chromosome X

2022-02-17

Abstract excerpt

Disease gene discovery on chromosome (chr) X is challenging owing to its unique modes of inheritance. We undertook a systematic analysis of human chrX genes. We observe a higher proportion of disorder-associated genes and an enrichment of genes involved in cognition, language, and seizures on chrX compared to autosomes. We analyze gene constraints, exon and promoter conservation, expression and paralogues, and rep...

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Literature Corpus work: 760b497e-b7ba-51e2-8998-6e47777491cc
DOI: 10.1101/2022.02.16.22270779

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