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Article

Flecainide sensitivity of a Na channel long QT mutation shows an open-channel blocking mechanism for use-dependent block.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2006

Zhu Yujie, Kyle John W, Lee Peter J

Abstract excerpt

A long QT mutation in the cardiac sodium channel, D1790G (DG), shows enhanced flecainide use-dependent block (UDB). The relative importance of open and inactivated states of the channel in flecainide UDB has been controversial. We used a modifiable, inactivation-deficient mutant channel that cont...

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Source

Identifiers

PMID: 16501012
DOI: 10.1152/ajpheart.01317.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16501012-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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