Article
Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma.
The Journal of investigative dermatology - 1 May 2006
Houben Roland, Michel Barbara, Vetter-Kauczok Claudia S, Pföhler Claudia, Laetsch Barbara, Wolter Manfred D, Leonard J Helen, Trefzer Uwe, Ugurel Selma, Schrama David, Becker Juergen C
Abstract excerpt
Merkel cell carcinoma (MCC) is a highly metastatic skin tumor. To assess the relevance of the Ras/Raf/MEK/MAP kinase pathway, we analyzed for activating B-Raf mutations and we elucidated the presence of the Raf Kinase Inhibitor Protein (RKIP) and extracellular signal-regulated kinase (ERK) as wel...
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