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Article

Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.

The Journal of investigative dermatology - 1 Aug 2008

Houben Roland, Vetter-Kauczok Claudia S, Ortmann Sonja, Rapp Ulf R, Broecker Eva B, Becker Juergen C

Abstract excerpt

Mutated BRAF and NRAS are suspected to contribute to melanomagenesis by activation of extracellular signal-regulated kinase (ERK). To test this notion, we analyzed the presence of phosphorylated ERK1/2 in 170 melanomas with established NRAS/BRAF mutational status and well-documented clinical foll...

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Share to Extracellular Signal-Regulated MAP Kinases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 18323787
DOI: 10.1038/jid.2008.30

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18323787-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma.PMID 18323787Read ↗

RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation.Semantic proximity Read ↗

Efficient Suppression of NRAS-Driven Melanoma by Co-Inhibition of ERK1/2 and ERK5 MAPK Pathways.Semantic proximity Read ↗

Lack of association between BRAF mutation and MAPK ERK activation in melanocytic nevi.Semantic proximity Read ↗

MIG6 Is MEK Regulated and Affects EGF-Induced Migration in Mutant NRAS Melanoma.Semantic proximity Read ↗

Absence of classical MAP kinase pathway signalling in Merkel cell carcinoma.Semantic proximity Read ↗

eIF4F controls ERK MAPK signaling in melanomas with BRAF and NRAS mutations.Semantic proximity Read ↗

Localization of active, dually phosphorylated extracellular signal-regulated kinase 1 and 2 in colorectal cancer with or without activating BRAF and KRAS mutations.Semantic proximity Read ↗

Fibroblast-derived neuregulin 1 promotes compensatory ErbB3 receptor signaling in mutant BRAF melanoma.Semantic proximity Read ↗

Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels.Semantic proximity Read ↗

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