Article
Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2006
Lan Yu, Ryan Rosemary C, Zhang Zunyi, Bullard Steven A, Bush Jeffrey O, Maltby Kathleen M, Lidral Andrew C, Jiang Rulang
Abstract excerpt
Cleft lip with or without cleft palate (CLP) is the most common craniofacial birth defect in humans. Recently, mutations in the WNT3 and Wnt9b genes, encoding two members of the Wnt family of signaling molecules, were found associated with CLP in human and mice, respectively. To investigate whether Wnt3 and Wnt9b directly regulate facial development, we analyzed their developmental expression patterns and found...
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