Article
Bardet-Biedl syndrome 3 regulates the development of cranial base midline structures.
Bone - 1 Aug 2017
Kawasaki Makiri, Izu Yayoi, Hayata Tadayoshi, Ideno Hisashi, Nifuji Akira, Sheffield Val C, Ezura Yoichi, Noda Masaki
Abstract excerpt
Bardet-Biedl Syndrome (BBS) is an autosomal recessive disorder and is classified as one of the ciliopathy. The patients manifest a characteristic craniofacial dysmorphology but the effects of Bbs3 deficiency in the developmental process during the craniofacial pathogenesis are still incompletely understood. Here, we analyzed a cranial development of a BBS model Bbs3-/- mouse. It was previously reported that these...
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