Article
PopGen: population-based recruitment of patients and controls for the analysis of complex genotype-phenotype relationships.
Community genetics - 1 Jan 2006
Krawczak Michael, Nikolaus Susanna, von Eberstein Huberta, Croucher Peter J P, El Mokhtari Nour Eddine, Schreiber Stefan
Abstract excerpt
OBJECTIVE: Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers. DESIGN: Precise estimates of population-specific genotypic risks can be obtained efficiently through the complete...
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