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Article

Behaviour of human heterochromatic regions during the synapsis of homologous chromosomes

16 Feb 2006

Abstract excerpt

BACKGROUND: Alterations of synapsis can disturb or arrest meiosis and result in infertility. Synaptic abnormalities are frequently observed in infertile patients but also in fertile men. METHODS: The subtelomere-specific multiplex fluorescence in-situ hybridization (stM-FISH) has been applied in combination with immunofluorescence to identify all synaptonemal complexes (SCs) and to analyse those presenting...

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PMID: 16484310
DOI: 10.1093/humrep/del028

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